BETA-LACTAM COMPOUNDS AND PRODUCTION THEREOF

BETA-LACTAM COMPOUNDS AND PRODUCTION THEREOF

An N-protected-3-acetyl-2-azetidinone-4-carboxylic acid ester has the formula: wherein R1 and R2 are protecting groups. The compounds are prepared by reacting a Schiff base R2-N=CH-COOR1 with diketene in the presence of an imidazole. In a further step the acetyl group is reduced and the carboxyl pro...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: SUNAGAWA, MAKOTO SUMITOMO KAGAKU SONE, SASAKI, AKIRA, ENOMOTO, MASAO SUMITO KAGAKU IBARAKI, GODA, KOSHIRO SUMITOMO KAGAKU SONE
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:An N-protected-3-acetyl-2-azetidinone-4-carboxylic acid ester has the formula: wherein R1 and R2 are protecting groups. The compounds are prepared by reacting a Schiff base R2-N=CH-COOR1 with diketene in the presence of an imidazole. In a further step the acetyl group is reduced and the carboxyl protecting group is then removed; the resultant beta -lactam compounds are useful as intermediates for the production of carbapenem or penem derivatives.