Beta-lactam compounds and production thereof

Beta-lactam compounds and production thereof

An N-protected-3-acetyl-2-azetidinone-4-carboxylic acid ester has the formula: wherein R1 and R2 are protecting groups. The compounds are prepared by reacting a Schiff base R2-N=CH-COOR1 with diketene in the presence of an imidazole. In a further step the acetyl group is reduced and the carboxyl pro...

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Bibliographische Detailangaben
Hauptverfasser: SUNAGAWA, MAKOTO SUMITOMO KAGAKU SONE, SASAKI, AKIRA, ENOMOTO, MASAO SUMITO KAGAKU IBARAKI, GODA, KOSHIRO SUMITOMO KAGAKU SONE
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:An N-protected-3-acetyl-2-azetidinone-4-carboxylic acid ester has the formula: wherein R1 and R2 are protecting groups. The compounds are prepared by reacting a Schiff base R2-N=CH-COOR1 with diketene in the presence of an imidazole. In a further step the acetyl group is reduced and the carboxyl protecting group is then removed; the resultant beta -lactam compounds are useful as intermediates for the production of carbapenem or penem derivatives.