Biphenylylpropionic acid derivative, process for preparing the same and pharmaceutical composition containing the same

Biphenylylpropionic acid derivatives of the formula: wherein R is an alkylcarbonyloxyalkyl group or an alkenylcarbonyloxyalkyl group having the formula: -@@-(CH2)m- O@R wherein R is hydrogen atom or a lower alkyl group having 1 to 5 carbon atoms, R is an alkyl group having 1 to 15 carbon atoms or an alkenyl group having 2 to 8 carbon atoms, and m is 0 or an integer of 1 provided that when R is a lower alkyl group, m is 0, or a lactone having the formula: wherein R and R are hydrogen atom or a lower alkyl group having 1 to 2 carbon atoms, and n is an integer of 1 or 2. The compounds have excellent anti-inflammatory, analgesic and antipyretic activities. Moreover, the compounds have no irritation, rapid and long acting and high safety margin.