POLYPEPTIDES WITH AN ANTAGONISTIC ACTIVITY ON SUBSTANCE P, PROCESS FOR THEIR PREPARATION, THEIR USE AND PROCESS FOR THE PURIFICATION OF POLYPEPTIDES

POLYPEPTIDES WITH AN ANTAGONISTIC ACTIVITY ON SUBSTANCE P, PROCESS FOR THEIR PREPARATION, THEIR USE AND PROCESS FOR THE PURIFICATION OF POLYPEPTIDES

Polypeptides of the formula I V-X-D-Trp-Y-D-Trp-Leu-Z-NH2 wherein V represents a naturally occurring aminoacid or a physiologically acceptable acid radical, X represents a naturally occurring aminoacid or a single bond, Y represents one of the aminoacids, Phe, Ile, Val, Tyr and L-p-Cl-Phe, and Z rep...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SCHULTHEISS, HARTMUT-BIOL, HORIG, JOACHIM-ERN
Format: Patent
Sprache:eng ; ger
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Polypeptides of the formula I V-X-D-Trp-Y-D-Trp-Leu-Z-NH2 wherein V represents a naturally occurring aminoacid or a physiologically acceptable acid radical, X represents a naturally occurring aminoacid or a single bond, Y represents one of the aminoacids, Phe, Ile, Val, Tyr and L-p-Cl-Phe, and Z represents the aminoacids Met or Nle, and salts thereof, in particular pharmaceutically acceptable salts thereof, a process for the preparation of these polypeptides and pharmaceutical products which contain these compounds. The invention also relates to a process for the purification of polypeptides by column chromatography.