Diazonium salts and reagents for bilirubin assay

Diazonium salts and reagents for bilirubin assay

Diazonium salts which are useful in an assay for bilirubin are disclosed. The novel salts have the structural formula: wherein X- is a stabilizing anion, Y is CO- or SO2-; and R1 and R2 are independently selected from hydrogen, alkyl, aryl, carboxyalkyl and hydroxyalkyl providing R1 and R2 are not b...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: BABB, BRUCE E, DAPPEN, GLEN M
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PHYSICS
TESTING
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Beschreibung
Zusammenfassung:Diazonium salts which are useful in an assay for bilirubin are disclosed. The novel salts have the structural formula: wherein X- is a stabilizing anion, Y is CO- or SO2-; and R1 and R2 are independently selected from hydrogen, alkyl, aryl, carboxyalkyl and hydroxyalkyl providing R1 and R2 are not both hydrogen; R3 and R4 are independently selected from groups such that the sum of the Hammett sigma values for R3 and R4 does not exceed +0.4 or R3 and R4 represent the carbon atoms necessary to complete a fused carbocyclic ring structure. Reagent compositions, analytical elements and methods which use the described diazonium salt are also disclosed.