LH-RH antagonists

LH-RH antagonists

Disclosed herein are peptide analogs of the luteinizing hormone releasing hormone (LH-RH) which are very potent antagonists of LHRH. These analogs are even active when administered through the oral route. They differ in structure from LH-RH by having other amino acid residues at the positions 1 and...

Ausführliche Beschreibung

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Bibliographische Detailangaben
1. Verfasser: COY, DAVID HOWARD
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Disclosed herein are peptide analogs of the luteinizing hormone releasing hormone (LH-RH) which are very potent antagonists of LHRH. These analogs are even active when administered through the oral route. They differ in structure from LH-RH by having other amino acid residues at the positions 1 and 2, by the presence of a basic amino acid residue at position 6 and by the optional presence of other amino acid residues at the positions 3 and 10.