New substituted 3-(parasubstituted)phenoxy-1-alkylamino-propanol-2-s, as well as process for their preparation, pharmaceutical preparations containing same, and method for treating cardiac failure

Compounds of the formula I wherein R is selected from the group consisting of hydrogen or methyl, m is an integer 0 or 1, whereby when m is 0, R and R are the same and are selected from the group consisting of methoxy, fluoro, bromo, and chloro in 2- and 6-position, whereby when m is 1, R is hydroge...

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Hauptverfasser: KAELLSSON, BRITT INGER MONICA, CARLSSON, ENAR INGEMAR, GUSTAFSSON, BILL BENJAMIN RUDOLF, MATTSSON, ANNIE HILLEVI
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:Compounds of the formula I wherein R is selected from the group consisting of hydrogen or methyl, m is an integer 0 or 1, whereby when m is 0, R and R are the same and are selected from the group consisting of methoxy, fluoro, bromo, and chloro in 2- and 6-position, whereby when m is 1, R is hydrogen and R is selected from the group consisting of hydrogen, methoxy, ethoxy, acetyl, methyl, hydroxymethyl, cyano, chloro, fluoro, bromo, or hydroxy, or a pharmaceutically acceptable salt thereof, as well as their preparation, pharmaceutical preparations containing the same, and method of treating cardiac failure. The compounds which possess beta-adrenoceptor stimulating activity are intended for treatment of cardiac disease whereby the compounds possess a pronounced inotropic effect.