Long duration neuromuscular blocking agents, pharmaceutical compositions containing them and processes for their preparation

This invention relates to long duration neuromuscular blocking agents, known examples of which agents have been found to have cardiovascular and other side effects, and seeks to overcome the shortcomings of presently used agents. The compounds of this invention are trans, tranS - 2,2 - (dimethyleneb...

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Bibliographische Detailangaben
Hauptverfasser: SWARINGEN, ROY ARCHIBALD, JR, YEOWELL, DAVID ARTHUR, EL-SAYAD, HASSAN ALI
Format: Patent
Sprache:eng ; fre ; ger
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Beschreibung
Zusammenfassung:This invention relates to long duration neuromuscular blocking agents, known examples of which agents have been found to have cardiovascular and other side effects, and seeks to overcome the shortcomings of presently used agents. The compounds of this invention are trans, tranS - 2,2 - (dimethylenebis(carbonyloxy-trimethylene))bis(1,2,3,4-tetrahydro-6,7,8 -trimethoxy-2-alkyl-1-(3,4,5-trimethoxybenzyl) isoquinolinium salts. A preferred compound has the following structure: l