Antibody targeted cytotoxic agent
Specific cytotoxic agents are provided comprising antibody specific for a surface antigen joined to a cytotoxic agent, desirably by a reductively cleavable linkage. Particularly, the cytotoxic portion of various toxins may be joined to a monoclonal antibody or fragment thereof by a disulfide linkage...
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creator | GILLILAND, DWIGHT GARY COLLIER, ROBERT JOHN |
description | Specific cytotoxic agents are provided comprising antibody specific for a surface antigen joined to a cytotoxic agent, desirably by a reductively cleavable linkage. Particularly, the cytotoxic portion of various toxins may be joined to a monoclonal antibody or fragment thereof by a disulfide linkage. The conjugate is found to be toxic for susceptible cells having the determinant site recognized by the receptor. The conjugates can be used for isolating mutant culture cells and therapeutically for destroying mutant cells present in a host. |
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Particularly, the cytotoxic portion of various toxins may be joined to a monoclonal antibody or fragment thereof by a disulfide linkage. The conjugate is found to be toxic for susceptible cells having the determinant site recognized by the receptor. The conjugates can be used for isolating mutant culture cells and therapeutically for destroying mutant cells present in a host.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>1982</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19820120&DB=EPODOC&CC=EP&NR=0044167A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19820120&DB=EPODOC&CC=EP&NR=0044167A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GILLILAND, DWIGHT GARY</creatorcontrib><creatorcontrib>COLLIER, ROBERT JOHN</creatorcontrib><title>Antibody targeted cytotoxic agent</title><description>Specific cytotoxic agents are provided comprising antibody specific for a surface antigen joined to a cytotoxic agent, desirably by a reductively cleavable linkage. Particularly, the cytotoxic portion of various toxins may be joined to a monoclonal antibody or fragment thereof by a disulfide linkage. The conjugate is found to be toxic for susceptible cells having the determinant site recognized by the receptor. The conjugates can be used for isolating mutant culture cells and therapeutically for destroying mutant cells present in a host.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1982</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFB0zCvJTMpPqVQoSSxKTy1JTVFIrizJL8mvyExWSExPzSvhYWBNS8wpTuWF0twMCm6uIc4euqkF-fGpxQWJyal5qSXxrgEGBiYmhmbmjkbGRCgBAFVtJX0</recordid><startdate>19820120</startdate><enddate>19820120</enddate><creator>GILLILAND, DWIGHT GARY</creator><creator>COLLIER, ROBERT JOHN</creator><scope>EVB</scope></search><sort><creationdate>19820120</creationdate><title>Antibody targeted cytotoxic agent</title><author>GILLILAND, DWIGHT GARY ; COLLIER, ROBERT JOHN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP0044167A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>1982</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>GILLILAND, DWIGHT GARY</creatorcontrib><creatorcontrib>COLLIER, ROBERT JOHN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GILLILAND, DWIGHT GARY</au><au>COLLIER, ROBERT JOHN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Antibody targeted cytotoxic agent</title><date>1982-01-20</date><risdate>1982</risdate><abstract>Specific cytotoxic agents are provided comprising antibody specific for a surface antigen joined to a cytotoxic agent, desirably by a reductively cleavable linkage. Particularly, the cytotoxic portion of various toxins may be joined to a monoclonal antibody or fragment thereof by a disulfide linkage. The conjugate is found to be toxic for susceptible cells having the determinant site recognized by the receptor. The conjugates can be used for isolating mutant culture cells and therapeutically for destroying mutant cells present in a host.</abstract><oa>free_for_read</oa></addata></record> |
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language | eng ; fre ; ger |
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subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
title | Antibody targeted cytotoxic agent |
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