Antibody targeted cytotoxic agent

Antibody targeted cytotoxic agent

Specific cytotoxic agents are provided comprising antibody specific for a surface antigen joined to a cytotoxic agent, desirably by a reductively cleavable linkage. Particularly, the cytotoxic portion of various toxins may be joined to a monoclonal antibody or fragment thereof by a disulfide linkage...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: GILLILAND, DWIGHT GARY, COLLIER, ROBERT JOHN
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Specific cytotoxic agents are provided comprising antibody specific for a surface antigen joined to a cytotoxic agent, desirably by a reductively cleavable linkage. Particularly, the cytotoxic portion of various toxins may be joined to a monoclonal antibody or fragment thereof by a disulfide linkage. The conjugate is found to be toxic for susceptible cells having the determinant site recognized by the receptor. The conjugates can be used for isolating mutant culture cells and therapeutically for destroying mutant cells present in a host.