PROCESS FOR PREPARING OMEGA-AMINO-1-HYDROXYALKYLIDENE-1, 1-BIS PHOSPHONIC ACIDS

PROCESS FOR PREPARING OMEGA-AMINO-1-HYDROXYALKYLIDENE-1, 1-BIS PHOSPHONIC ACIDS

A process for the preparation of a omega -amino-1-hydroxyalkylidine-1,1-biphosphonic acid of the formula wherein n is an integer from 3 to 5, consisting essentially of the steps of reacting an aminocarboxylic acid of the formula NH2-CH2-(CH2)m-COOH wherein m is an integer from 2 to 4, with a phospho...

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Bibliographische Detailangaben
Hauptverfasser: BLUM, HELMUT, WORMS, KARL-HEINZ
Format: Patent
Sprache:eng ; ger
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
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Zusammenfassung:A process for the preparation of a omega -amino-1-hydroxyalkylidine-1,1-biphosphonic acid of the formula wherein n is an integer from 3 to 5, consisting essentially of the steps of reacting an aminocarboxylic acid of the formula NH2-CH2-(CH2)m-COOH wherein m is an integer from 2 to 4, with a phosphonating reactant selected from the group consisting of (a) a mixture of phosphorous acid and PCl3, (b) a mixture of phosphorous acid and PCl5, and (c) a mixture of phosphorous acid and POCl3, hydrolyzing the reaction mixture with a strong acid which does not oxidize aminophosphonic acids, and recovering said omega -amino-1-hydroxyalkylidene-1,1-bisphosphonic acid.