Substituted benzamides

Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein: R1 is a C1-6 alkoxy group; R2 and R3 are the same or different and are hydrogen @halogen@ CF3, C1-7 acyl, C1-7 acylamino, C1-6 alkyl-S(O)n wherein n is 0, 1 or 2 nitro, or amino, aminocarbonyl or aminosulphonyl optional...

Ausführliche Beschreibung

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Bibliographische Detailangaben
1. Verfasser: HADLEY, MICHAEL STEWART
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein: R1 is a C1-6 alkoxy group; R2 and R3 are the same or different and are hydrogen @halogen@ CF3, C1-7 acyl, C1-7 acylamino, C1-6 alkyl-S(O)n wherein n is 0, 1 or 2 nitro, or amino, aminocarbonyl or aminosulphonyl optionally substituted by one or two C1-6 alkyl groups; or R1 and R2 taken together are methylendioxy or ethylenedioxy in which case R3 is any one of the groups given for R1 and R2 above; R4 is hydrogen or C1-6 alkyl; R5 is hydrogen, C1-6 alkyl, phenyl or phenyl-C1-6 alkyl, either of which phenyl moieties may be substituted by C1-6 alkyl, C1-6 alkoxy, CF3 or halogen, and R6 is hydrogen; or R5 and R6 are attached to two adjacent carbon atoms and form together with these two carbon atoms a fused benzene ring, which benzene ring may be substituted by C1-6 alkyl, C1-6 alkoxy, CF3 or halogen; and j is 1 to 4; and p is 0 to 2 and q is 0 to 3, having useful pharmacological activity, a process for their preparation and their use.