7-OXO-PGI2 DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS

7-OXO-PGI2 DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS

1. Optically active and racemic 7-oxo-PGl2 derivatives of general formula see diagramm : EP0031426,P12,F1 wherein Q represents hydrogen, a physiologically acceptable cation or C1-6 alkyl, X represents cis or trans -CH=CH-, -C-=C- or -CH2 -CH2 -, R**13 represens hydrogen, C1-4 alkanoyl, a protecting...

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Hauptverfasser: SIMONIDESZ, VILMOS, IVANICS, JOZSEF, PALLAGI, ISTVAN, STADLER, ISTVAN, PAPP GEB. BEHR, AGNES, DER GEB. FOLDVARY, JULIA, KOVACS, GABOR
Format: Patent
Sprache:eng ; ger
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:1. Optically active and racemic 7-oxo-PGl2 derivatives of general formula see diagramm : EP0031426,P12,F1 wherein Q represents hydrogen, a physiologically acceptable cation or C1-6 alkyl, X represents cis or trans -CH=CH-, -C-=C- or -CH2 -CH2 -, R**13 represens hydrogen, C1-4 alkanoyl, a protecting group of general formula R**7R**8R**9Si-or see diagramm : EP0031426,P12,F2 wherein R**7, R**8 and R**9, which may be indentical or different, represent C1-4 alkyl, R**10 and R**11, which may be identical or different represent hydrogen or methyl and R**12 represents methyl or ethyl, or the tetrahydropyran-2-yl group, R**4 represents hydrogen, C1-6 alkyl in the steric alpha or beta configuration, R**1 and R**2 represent hydrogen or C1-6 alkyl Y represents methylene, oxygen or -NH- and R**3 represents C1-6 alkyl or phenyl which may be monosubstituted by halogen-substituted C1-6 alkyl, hydroxyl, mercapto, C1-6 alkanoyloxy, benzoyloxy, amino, mono- or di-C1-6 alkylamino, halogen, C1-6 alkoxy or C1-6 alkylthio.