1,2,3,4-TETRAHYDRO-6-OXO-2,8A-METHANO-6H-DIBENZ(C,E)-AZOCINES, MEDICAMENTS CONTAINING THEM, AND PROCESS FOR THEIR PREPARATION

Azocine derivatives, their pharmacologically acceptable salts, and a process for their production are disclosed. The compounds, which display analgesic effects in mammals, have the formula:- wherein R is a hydrogen atom, a straight or branched chain alkyl radical having from 1 to 8 carbon atoms, a straight or branched chain alkenyl radical having from 2 to 6 carbon atoms, a cycloalkyl radical having from 3 to 7 carbon atoms, a cycloalkyl-alkyl radical having from 4 to 8 carbon atoms, the 2-or 3-furylmethyl radical optionally substituted by 1 to 3 methyl radicals. the 2- or 3-tetrahydrofurylmethyl radical optionally substituted by 1 to 3 methyl radicals, or a radical of the following formula: wherein n is 1, 2, or 3; m is 0, 1, or 2; p is 0 or 1, or, when R is a lower alkoxy radical, is 0,1,2 or 3; R is a halogen atom; R is a hydroxy, methyl or trifluoromethyl radical, a lower alkoxy radical having from 1 to 3 carbon atoms, or an alkanoyloxy radical having from 1 to 6 carbon atoms, or, when m and p each represent at least 1, R and R together form a methylenedioxy group; R is a hydroxy radical or an alkoxy radical having from 1 to 6 carbon atoms; R is a hydrogen atom or an alkoxy radical having from 1 to 6 carbon atoms: or R and R when taken together form a methylenedioxy group; and R@ an alkoxy radical having from 1 to 6 carbon atoms or a benzyloxy radical; and can be prepared by oxidative cyclization of compounds of formula: where R, R , R , R and R are selected substituents.