Antithrombotic compositions containing benzisothiazolones

This invention relates to a pharmaceutical composition useful in the treatment of arterial thrombosis. A combination of a non-steroidal anti-inflammatory agent with a benzisothiazolone of formula (I) is found to be capable of inhibiting the aggregation of blood platelets to a greater degree than eac...

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Bibliographische Detailangaben
Hauptverfasser:	NUNN, BARBARA, BAGGALEY, KEITH HOWARD
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	This invention relates to a pharmaceutical composition useful in the treatment of arterial thrombosis. A combination of a non-steroidal anti-inflammatory agent with a benzisothiazolone of formula (I) is found to be capable of inhibiting the aggregation of blood platelets to a greater degree than each of the components separately. R and R represent a variety of substituent groups; X represents a bond or an alkylene chain; and R represents a heterocyclic group. When the anti-inflammatory agent contains a carboxylic acid group, the combination with compound (I) may be in the form of a salt.