2-SUBSTITUTED-3-PHENYLINDOLES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

2-SUBSTITUTED-3-PHENYLINDOLES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

The invention relates to novel 3-phenyl-indoles of the formula wherein X and Y are independently hydrogen or halogen atoms; each n is 1, 2 or 3, Q is an oxygen atom or the group (H,OH), Z is a hydrogen atom, or provided that Q is an oxygen atom, Z can also be the group OR, wherein R is a hydrogen at...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: TAHBAZ, PIROUZ, STEINMAN, MARTIN
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention relates to novel 3-phenyl-indoles of the formula wherein X and Y are independently hydrogen or halogen atoms; each n is 1, 2 or 3, Q is an oxygen atom or the group (H,OH), Z is a hydrogen atom, or provided that Q is an oxygen atom, Z can also be the group OR, wherein R is a hydrogen atom or a lower alkyl or loweralkoxy-loweralkyl group, "lower" indicating groups with 1-6 carbon atoms, m is 1 or 2 when Z is a hydrogen atom and m is O when Z is the group OR, to their preparation, and to pharmaceutical compositions containing them. These compounds have immunosuppressant activity and can be used for example in the treatment of rheumatoid arthritis.