INHIBIDORES DE LA TIROSINA QUINASA DE BRUTON

1. Un compuesto de la Fórmula I: V2 V1 N N R1 R6 R4 R11 LR 3 n k Fórmula I o un estereoisómero, solvato o sal farmacéuticamente aceptable de este, en donde: V1 es C o N, V2 es C(R2) o N, de manera que si V1 es С entonces V2 es N, si V1 es С entonces V2 es С(R2), o si V1 es N entonces V2 es С(R2); ca...

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Hauptverfasser:	SMIRNOVA, Svetlana Sergeevna, GORBUNOVA, Svetlana Leonidovna, SILONOV, Sergey Aleksandrovich, MIKHAYLOV, Leonid Evgen`evich, KOZHEMYAKINA, Natalia Vladimirovna, POPKOVA, Aleksandra Vladimirovna, IAKOVLEV, Pavel Andreevich, KUSHAKOVA, Anna Sergeevna, MOLDAVSKY, Alexander, GAVRILOV, Aleksey Sergeevich, ALESHUNIN, Pavel Aleksandrovich, REKHARSKY, Mikhail Vladimirovich, KUKUSHKINA, Anna Aleksandrovna
Format:	Patent
Sprache:	spa
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	1. Un compuesto de la Fórmula I: V2 V1 N N R1 R6 R4 R11 LR 3 n k Fórmula I o un estereoisómero, solvato o sal farmacéuticamente aceptable de este, en donde: V1 es C o N, V2 es C(R2) o N, de manera que si V1 es С entonces V2 es N, si V1 es С entonces V2 es С(R2), o si V1 es N entonces V2 es С(R2); cada n, k es independientemente 0, 1; cada R2, R11 es independientemente H, D, Hal, CN, NR’R’’, C(O)NR’R’’, alcoxi C1-C6; R3 es H, D, hidroxi, alquilo С(O)C1-C6, alquenilo С(О)С2-С6, alquinilo С(О)С2-С6, alquilo C1-C6; R4 es H, Hal, CN, CONR’R’’, hidroxi, alquilo C1-C6, alcoxi C1-C6; L es CH2, NH, О o enlace químico; R1 se selecciona del grupo de fragmentos, que consiste en: A1 A2 A4 A3 N O R5 R5 Fragmento 1, A1 A2 A4 A3 O A9 A8 A7 A6 A5 R5 Fragmento 2, The present invention relates to a new compound of formula I: or pharmaceutically acceptable salt, solvate or stereoisomer thereof, wherein: V1 is C or N, V2 is C(R2) or N, whereby if V1 is C then V2 is N, if V1 is C then V2 is C(R2), or if V1 is N then V2 is C(R2); each n, k is independently 0, 1; each R2, R11 is independently H, D, Hal, CN, NR'R", C(O)NR'R", C1-C6 alkoxy; R3 is H, D, hydroxy, C(O)C1-C6 alkyl, C(O)C2-C6 alkenyl, C(O)C2-C6 alkynyl, C1-C6 alkyl; R4 is H, Hal, CN, CONR'R", hydroxy, C1-C6 alkyl, C1-C6 alkoxy; L is CH2, NH, O or chemical bond; R1 is selected from the group of the fragments, comprising: Fragment 1, Fragment 2, Fragment 3 each A1, A2, A3, A4 is independently CH, N, CHal; each A5, A6, A7, A8, A9 is independently C, CH or N; R5 is H, CN, Hal, CONR'R", C1-C6 alkyl, non-substituted or substituted by one or more halogens; each R' and R" is independently selected from the group, comprising H, C1-C6 alkyl, C1-C6 cycloalkyl, aryl; R6 is selected from the group: [formula II] each R7, R8, R9, R10 is independently vinyl, methylacetylenyl; Hal is CI, Br, I, F, which have properties of inhibitor of Bruton's tyrosine kinase (Btk), to pharmaceutical compositions containing such compounds, and their use as pharmaceuticals for treatment of diseases and disorder.