SYNTHESIS OF N4-(2,2-DIMETHYL-4-[(DIHYDROPHOSPHONOXY)METHYL]-3-OXO-5-PYRIDO[1,4]OXAZIN-6-YL)-5-FLUORO-N2-(3,4,5-TRIMETHOXYPHENYL)-2,4-PYRIMIDINEDIAMINE DISODIUM SALT

SYNTHESIS OF N4-(2,2-DIMETHYL-4-[(DIHYDROPHOSPHONOXY)METHYL]-3-OXO-5-PYRIDO[1,4]OXAZIN-6-YL)-5-FLUORO-N2-(3,4,5-TRIMETHOXYPHENYL)-2,4-PYRIMIDINEDIAMINE DISODIUM SALT

This invention relates to the field of pharmaceutical/process chemistry. Disclosed herein is a process for preparing N4-(2,2-dimethyl-4-[(dihydrophosphonoxy)methyl]-3-oxo-5-pyrido[1,4]oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine disodium salt, particularly hydrates (such a...

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Bibliographische Detailangaben
Hauptverfasser: GISELBRECHT KARL-HEINZ, WOLBERG MICHAEL, FELFER ULFRIED
Format: Patent
Sprache:eng ; rus
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:This invention relates to the field of pharmaceutical/process chemistry. Disclosed herein is a process for preparing N4-(2,2-dimethyl-4-[(dihydrophosphonoxy)methyl]-3-oxo-5-pyrido[1,4]oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine disodium salt, particularly hydrates (such as a hexahydrate). The compound is useful in the treatment and prevention of various diseases. Also disclosed is a process of preparing N4-(2,2-dimethyl-4-[(dihydrophosphonoxy)methyl]-3-oxo-5-pyrido[1,4]oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine. Both processes involve the use of an amide. Это изобретение относится к области фармацевтической/технологической химии. В настоящем документе описан способ получения динатриевой соли N4-(2,2-диметил-4-[(дигидрофосфонокси)метил]-3-оксо-5-пиридо[1,4]оксазин-6-ил)-5-фтор-N2-(3,4,5-триметоксифенил)-2,4-пиримидиндиамина, в частности гидратов (таких как гексагидрат). Это соединение пригодно для лечения и профилактики различных заболеваний. Также описан способ получения N4-(2,2-диметил-4-[(дигидрофосфонокси)метил]-3-оксо-5-пиридо[1,4]оксазин-6-ил)-5-фтор-N2-(3,4,5-триметоксифенил)-2,4-пиримидиндиамина. Оба способа включают применение амида.