PHARMACEUTICAL COMBINATION OF 5-FLUOROURACIL AND DERIVATE OF 1,4-DIHYDROPYRIDINE AND ITS USE IN THE TREATMENT OF CANCER

PHARMACEUTICAL COMBINATION OF 5-FLUOROURACIL AND DERIVATE OF 1,4-DIHYDROPYRIDINE AND ITS USE IN THE TREATMENT OF CANCER

New compounds of 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid ester type having general formula (I)wherein R is a lower alkyl group, which is methyl or ethyl, and R1 and R2 is sodium carboxylate-methyl ester, wherein said compounds have synergistic cytotoxic effect combined with 5-fluorour...

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Hauptverfasser: VIGANTE BRIGITA, POIKANS JANIS, DOMRACEVA ILONA, SESTAKOVA IRINA, DUBURS GUNARS, JASCENKO ELINA, BRUVERE IMANTA, KALVINSH IVARS, BISINIEKS EGILS, ULDRIKIS JANIS, STONANS ILMARS
Format: Patent
Sprache:eng ; rus
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:New compounds of 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid ester type having general formula (I)wherein R is a lower alkyl group, which is methyl or ethyl, and R1 and R2 is sodium carboxylate-methyl ester, wherein said compounds have synergistic cytotoxic effect combined with 5-fluorouracil. Новые соединения типа сложного эфира 2,6-диметил-1,4-дигидропиридин-3,5-дикарбоновой кислоты, имеющие общую формулу (I)где R представляет собой низшую алкильную группу, которая является метилом или этилом, a R1 и R2 представляют собой натрийкарбоксилатметиловый эфир, причем указанные соединения обладают синергичным цитотоксическим эффектом при сочетании с 5-фторурацилом.