AMINOTHIAZOLE DERIVATIVES AND THEIR USE AS CRF RECEPTOR LIGANDS

1. A compound of formula (I): in which R1 and R2, which may be identical or different, each independently represent a halogen atom; a hydroxy (C1-C5)alkyl; a (C1-C5)alkyl; an aralkyl in which the aryl portion is (C6-C8) and the alkyl portion is (C1-C4); a (C1-C5)alkoxy; a trifluoromethyl group; a ni...

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Bibliographische Detailangaben
Hauptverfasser: FONTAINE, EVELYNE, GESLIN, MICHEL, GULLY, DANIELLE, ROGER, PIERRE, PRADINES, ANTOINE
Format: Patent
Sprache:eng ; rus
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Beschreibung
Zusammenfassung:1. A compound of formula (I): in which R1 and R2, which may be identical or different, each independently represent a halogen atom; a hydroxy (C1-C5)alkyl; a (C1-C5)alkyl; an aralkyl in which the aryl portion is (C6-C8) and the alkyl portion is (C1-C4); a (C1-C5)alkoxy; a trifluoromethyl group; a nitro group; a nitrile group; a group -SR in which R represents hydrogen, a (C1-C5)alkyl or an aralkyl in which the aryl portion is (C6-C8) and the alkyl portion is (C1-C4); a group -S-CO-R in which R represents a (C1-C5)alkyl or an aralkyl radical in which the aryl portion is (C6-C8) and the alkyl portion is (C1-C4); a group -COORa in which Ra represents hydrogen or a (C1-C5)alkyl; a group -CONRaRb with Ra and Rb as defined above for Ra; a group -NRaRb with Ra and Rb as defined above for Ra; a group -CONRcRd or -NRcRd in which Rc and Rd constitute, with the nitrogen atom to which they are attached, a 5- to 7-membered heterocycle; or a group -NHCO-NRaRb with Ra and Rb as defined above for Ra; R3 represents hydrogen or is as defined above for R1 and R2; or alternatively R2 constitutes with R3, when the latter substitutes the phenyl in position 5, a represents a (C1-C6)alkyl; a (C1-C6)alkoxy(C1-C3)alkyl; a (C3-C5)cycloalkyl; a (C3-C6) group -X-CH2-X- in which X independently represents a CH2 or an oxygen or sulphur atom; R6 cycloalkyl(C1-C6)alkyl; a (C1-C6)alkylthio(C1-C3)alkyl; a (C1-C6)alkylsulphoxy(C1-C3)alkyl; or a (C1-C6)alkylsulphodioxy(C1-C3)alkyl; R7 represents a phenyl which is unsubstituted, mono-, di- or trisubstituted in position 3, 4 or 5 with a halogen, with a (C1-C5)alkyl, with an -O-CH2-O- group on two neighbouring carbon atoms of the phenyl, with a -CF3, -NO2 or -CN, with a group -COOR8 or -CONR8R9 or with a group CH2OR8 in which R8 and R9 represent a (C1-C3)alkyl, OR10 in which R represents a (C1-C5)alkyl; or alternatively R7 represents a pyridyl, thiophene, pyrazolyl, imidazolyl, (C3-C5)cycloalkyl or (C3-C6)cycloalkyl(C1-C6)alkyl group; or the acid or base addition salts thereof, the hydrates thereof and/or the solvates thereof. 2. A compound according to claim 1 wherein: R1 and R2, which may be identical or different, each independently represent a halogen atom; a (C1-C5)alkyl; or a (C1-C5)alkoxy; R3 represents hydrogen or is as defined above for R1 and R2; R6 represents a (C1-C6)alkyl; a (C1-C6)alkoxy(C1-C3)alkyl; a (C3-C5)cycloalkyl; or a (C3-C6)cycloalkyl(C1-C6)alkyl; R7 represents a phenyl which is unsubstituted or mono- or disubstituted in p