RESORCINOL DERIVATIVES

1. A compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein: R is a (C3-C8) cycloalkyl ring or (C5-C8) cycloalkenyl ring, wherein either the cycloalkyl ring or cycloalkenyl ring is substituted by one to three substituents independently selected from the group consisting of c...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: PROCTER, MARTIN, JAMES, COLLINGTON, ERIC, WILLIAM, GEDEN, JOANNA, VICTORIA, BROWNING, ANDREW, FRANCIS
Format: Patent
Sprache:eng ; rus
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:1. A compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein: R is a (C3-C8) cycloalkyl ring or (C5-C8) cycloalkenyl ring, wherein either the cycloalkyl ring or cycloalkenyl ring is substituted by one to three substituents independently selected from the group consisting of cyano; halo; (C1-C6) alkyl; aryl; (C2-C9) heterocycloalkyl; (C2 C9) heteroaryl; aryl (C1-C6) alkyl-; =O; =CHO (C1-C6) alkyl; amino; hydroxy; (C1-C6) alkoxy; aryl(C1-C6)alkoxy-; aryl(C1-C6)alkoxy-; (C1-C5)acyl; amino(C1-C6)alkyl-; aryl(C1-C6)alkylamino-; (C1-C6) alkoxy-CO-NH-; (C1-C6)alkylamino-CO-; (C2-C6)alkenyl; (C2-C6) alkynyl; hydroxy(C1-C6)alkyl; acyloxy(C1-C6)alkyl-; nitro; cyano(C1-C6)alkyl-; halo(C1-C6)alkyl-; (C1-C6)alkoxy(C1-C6)alkyl-; trifluoromethyl; trifluoromethyl(C1-C6)alkyl-; (C1-C6 halo(C1-C6)alkyl-; nitro(C1-C6)alkyl-; (C1-C6) acylamino-; (C1-C6)acylamino(C1-C6)alkyl-; (C1-C6)alkoxy(C1-C6)acylamino-; amino(C1-C6)alkylamino(C1-C6)acyl-; ((C1-C6)C6)acyl-; amino(C1-C6)acyl(C1-C6)alkyl-; alkyl)2amino(C1-C6)acyl-; -CO2R ; -(C1-C6)alkyl-CO2R ; -C(O)N(R )2; -(C1-C6) alkyl-C(O)N(R )2; R ON=; -NR (OR ); -(C1-C6)alkyl-NR (OR ); -R ON=CR (C1-C6)alkyl-; C(O)(NR OR ); -(C1-C6)alkyl-C(O)(NR OR ); -S(O)mR ; wherein each R is independently selected from hydrogen, (C1-C6) alkyl, aryl, or aryl(C1-C6)alkyl-; R C(O)O-, wherein R is (C1-C6) alkyl, aryl, or aryl (C1-C6) alkyl-; R C(O)O-(C1-C6)alkyl-; R R N-C(O)-O-; R R NS(O)2-; R R NS(O)2(C1-C6) alkyl-; R S(O)R N-; R S(O)2R N(C1-C6)alkyl-; wherein m is 0,1 or 2, and R and R are each independently selected from hydrogen or (C1-C6)alkyl; -C (=NR ) (N (R )2); or -(C1-C6)alkyl-C(=NR ) (N(R )2) wherein R represents OR or R wherein R is defined as above; with the proviso that the cycloalkenyl ring is not aromatic; with the proviso that R must be substituted by at least one of R C(O)O-(C1-C6)alkyl-; R ON=; R ON=(C1-C6)alkyl-; R ON=CR (C1-C6)alkyl-; NR (OR ); R R NS(O)2-; R R NS(O)2(C1-C6)alkyl-; R S(O)2R N-or R S(O)2R N(C1-C6)alkyl-; with the proviso that when R is only substituted by one of R ON=, then R cannot be hydrogen. 2. The compound of claim 1, wherein R is a cyclohexyl or cyclohexenyl ring substituted at the 3- or 4-position, or a cyclopentyl or cyclopentenyl ring substituted at the 3 position. 3. The compound of claim 1, wherein R is monosubstituted. 4. The compound of claim 1, wherein R is disubstituted. 5. The compound of claim 1, wherein R is substituted by R C(O)O-(C1-C6)alkyl-. 6. The compound of claim 1, whe