METHOD FOR SEPARATING AND/OR ISOLATING PLASMA PROTEINS BY ANNULAR CHROMATOGRAPHY

1. A process for the separation and/or isolation of human plasma proteins, from a blood plasma or a mixture containing virus-inactivated plasma proteins using the method of annular chromatography, characterized in that, the separation is made in separation medium wherein having a layer of application medium which is spherical particles with hydrophobic surface. 2. The process according to claim 1, characterized in that said mixture contains at least two plasma proteins to be separated. 3. The process according to claim 1, wherein said separation medium having the annular design is used for ion-exchange, gel permeation, molecular size exclusion or affinity chromatography or chromatography based on hydrophobic interactions. 4. The process according to claims 1, wherein said plasma proteins are inter-alpha-trypsin inhibitor, alpha1-antitrypsin, anti-thrombin III, immune globulins, such as IgG, human serum albumin or glycoproteins, preferably from the clotting cascade, or vitamin K dependent blood clotting factors. 5. The process according to at least one of claims 1, characterized in that said plasma proteins are selected from blood clotting factors VIII, IX, and thrombin. 6. The process according to any of claims 1, characterized in that the functions of mixing, of separating the plasma proteins and of the fractioning are performed continuously. 7. The process according to any of claims 1, characterized in that the separation medium is continuously regenerated and equilibrated, simultaneously with the separation of the plasma proteins. 8. The process according to any of claims 1, characterized in that when a material for adsorption chromatography is used as the separation medium, at least two different eluents are simultaneously passed through said separation medium having the annular design. 9. The process according to any of claims 1, characterized in that at least two different separation media are employed in layers. 10. The process according to any of claims 1, characterized in that a polymeric block material is employed as said separation medium. Способ разделения и/или выделения протеинов плазмы, в особенности протеинов плазмы человека, из смеси, содержащей протеины плазмы, в котором указанную смесь наносят на разделяющую среду, имеющую кольцевую конфигурацию и имеющую слой нанесенной на него аппликационной среды; указанная разделяющая среда, имеющая кольцевую конфигурацию, вращается, в основном, вертикально вокруг оси, которая определена в направлени