SUBSTITUEREDE 2-(BETA-NAPHTHYLOXY)-ETHYLPYRAZOLONER FREMGANGSMADE TIL FREMSTILLING DERAF OG DERES ANVENDELSE SOM LEGEMIDDEL

Pyrazolones of formula (I), including the tautomers are novel cpds. (where R1 = H, CF3 or an opt. substd. alkyl, aryl, aralkyl or heteroaryl group and R2 = unsubstd. naphthyl where R1 = H, CF3, >4C alkyl, heteroaryl or substd. aryl or aralkyl otherwise R2 = naphthyl substd. by 1-3 substituents in...

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Hauptverfasser:	SEUTER F, MENG K A, MOELLER E, HORSTMANN H
Format:	Patent
Sprache:	dan
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	Pyrazolones of formula (I), including the tautomers are novel cpds. (where R1 = H, CF3 or an opt. substd. alkyl, aryl, aralkyl or heteroaryl group and R2 = unsubstd. naphthyl where R1 = H, CF3, >4C alkyl, heteroaryl or substd. aryl or aralkyl otherwise R2 = naphthyl substd. by 1-3 substituents independently chosen from halo, CF3, alkyl, alkenyl, alkoxy, alkylamino, cyano, CF3O, nitro, hydroxy, -SOn- alkyl or SOnCF3 ( n = 0-2), two of the substituents may be joined to form a 5-7 membered, opt. unsaturated, opt. branched isocyclic or heterocyclic ring which may contain 1 or 2 atoms of O or S or R2 = biphenylyl. Cpds. may be administered orally or parenterally for therapeutic or prophylactic treatment of thrombo-embolic disorders, blood clots, etc. Pred. daily doses are 0.1-10 mg/kg parenterally or 0.5-100 mg/kg orally. A typical product is (I) where R2 = beta-naphthyl and R1 = 2-methoxy-isobutyl prepd. from 2-(beta-napthyloxylethyl hydrazine and ethyl (beta, beta-dimethyl-beta-methoxy-propionyl) acetate.