FREMGANGSMAADE TIL FREMSTILLING AF FLUOXETIN-HYDROKLORID

An improved process for the preparation of a valuable drug. The present invention relates to an improved process for the preparation of N-methyl-3-(p-trifluoromethylphenoxy)-3-phenyl-propylamine of formula (I), or a pharmaceutically acceptable acid addition salt thereof, characterized in that 2-benz...

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Bibliographische Detailangaben
Hauptverfasser:	KAIRISALO, PEKKA JUHANI, JAERVINEN, ANITTA HANNELE, HUKKA, PETRI JUHANI
Format:	Patent
Sprache:	dan
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	An improved process for the preparation of a valuable drug. The present invention relates to an improved process for the preparation of N-methyl-3-(p-trifluoromethylphenoxy)-3-phenyl-propylamine of formula (I), or a pharmaceutically acceptable acid addition salt thereof, characterized in that 2-benzoyl-N-benzyl-N-methylethylamine base of formula (II), is hydrogenated catalytically, whereby 1-phenyl-3-(N-methylamino)propane-1-ol of formula (III) is formed, which is thereafter etherified selectively with 1-chloro-4-trifluoromethylbenzene of formula (IV), in the presence of a base, whereby N-methyl-3-(p-trifluoromethylphenoxy)-3-phenyl-propylamine is formed, which is optionally converted in a known manner into the acid addition salt of Fluoxetine, e.g. Fluoxetine hydrochloride. The yield of Fluoxetine hydrochloride is 85-87% of the theoretical yield.