BASISKE ETHERE AF 7-OXO-7H-BENZO (C) FLUOREN OG EN FREMGANGSMAADE TIL DERES FREMSTILLING

BASISKE ETHERE AF 7-OXO-7H-BENZO (C) FLUOREN OG EN FREMGANGSMAADE TIL DERES FREMSTILLING

Basic ethers of 7-oxo-7H-benzo(c) fluorene have been shown to evidence a pronounced antineoplastic and immunosuppressive effect in mammals suffering from leukemia. The technique for preparing the described ethers and the addition salts thereof with pharmaceutically acceptable organic and inorganic a...

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Hauptverfasser: REZABEK K, VANCUROVA I, PUJMAN V, CERNOCHOVA S, POKORNA S, KREPELKA J, MELKA M, REICHLOVA R
Format: Patent
Sprache:dan
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ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Basic ethers of 7-oxo-7H-benzo(c) fluorene have been shown to evidence a pronounced antineoplastic and immunosuppressive effect in mammals suffering from leukemia. The technique for preparing the described ethers and the addition salts thereof with pharmaceutically acceptable organic and inorganic acids involves the aminoalkylation of 5-hydroxy-7-oxo-7H-benzo(c) fluorene and its corresponding nuclear substituted derivatives on the hydroxylic oxygen atom.