ANALOGIFREMGANGSMAADE TIL FREMSTILLING AF 2-AMINO-3-BENZOYLPHENYLACETAMIDER OG DERES CYCLISKE HOMOLOGE

2-Amino-3-benzoyl-phenylacetamides are provided having the formula: wherein: R represent hydrogen or lower alkyl, R and R represent hydrogen, lower alkyl, cycloalkyl, phenyl and phenyl substituted by lower alkyl, lower alkoxy, halogen, nitro and trifluoromethyl, and R and R when taken together with...

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Hauptverfasser: WALSH D A, SHANKLIN J R, SHAMBLEE D A
Format: Patent
Sprache:dan
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Zusammenfassung:2-Amino-3-benzoyl-phenylacetamides are provided having the formula: wherein: R represent hydrogen or lower alkyl, R and R represent hydrogen, lower alkyl, cycloalkyl, phenyl and phenyl substituted by lower alkyl, lower alkoxy, halogen, nitro and trifluoromethyl, and R and R when taken together with the adjacent nitrogen may form a heterocyclic residue; X represents hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl; Y represents hydrogen, lower alkyl, lower alkoxy, halogen, trifluoromethyl, lower alkylthio, lower alkyloxythio or lower alkyldioxythio; Am is primary amino (-NH2), methylamino or dimethylamino, and n is 1 to 2 inclusive. The compounds exhibit anti- inflammatory, antipyretic, anti-blood platelet aggregation and analgetic pharmacological activities.