4-AMINOQUINOLINDERIVATER OG EN FREMGANGSMAADE TIL FREMSTILLING DERAF

4-Ainoquinoline derivaties having the general formula …… and their pharmaceutically acceptable acid addition salts, wherein X is trifluoromethyl or halogen, Z is hydrogen, halogen, lower alkyl, lower alkoxy, nitro, di(lower alkyl) amino or trifluoromethyl and R is a group having one of the formulae …… -NR -A-NR R (VI)… and …… wherein R is hydrogen or lower alkyl, R is lower alkyl, R is lower alkyl and A is lower alkylene, are disclosed. The 4-aminoquinoline derivatives may be prepared by acylation of an amine RH or an activated derivative thereof with an acid (formula IV, R = OH) or a reactive derivative thereof or by reacting aniline substituted on the ring by Z and -COR to introduce the 8-(trifluoromethyl or halo) -4-quinolyl radical. The 4-aminoquinoline derivatives show analgesic activity and, in some cases, anti-inflammatory activity and may therefore be included in pharmaceutical compositions containing a pharmaceutically acceptable carrier.