Fremgangsmåde til syntetisering af N-substitueret phenyl-5-hydroxymethyl-2-oxazolidinon

The invention discloses a method for synthesizing N-substituted phenyl-5-hydroxymethyl-2-oxazolidinone, wherein the method comprises: reacting from raw materials, 3-R2-4-R1-aniline and epichlorohydrin, and allowing the resulting product to react under alkaline conditions in a CO2 atmosphere to obtain N-substituted phenyl-5-hydroxymethyl-2-oxazolidinone, wherein R1 is a morpholine group, a morpholin-3-one group or a piperazine group, and derivative groups thereof, and R2 is halogen, hydrogen or lower alkyl. The method provided by the invention has such advantages as few steps, simple operation, cheap and easily available raw materials, mild reaction conditions, and high product yield, and is especially suitable for industrial production of antibiotic linezolid intermediates and antithrombotic drug rivaroxaban intermediates.