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An object of the present application is to provide new anti-Fc epsilon R-antibodies which enable B cells to be identified at a specific differentiation stage as well enabling the different degrees of atopy and Fc epsilon -receptor expression to be defined as a result by the showing that Fc epsilon R...

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Bibliographische Detailangaben
Hauptverfasser:	SUEMURA, MASAKI, BARSUMIAN, EDWARD L, KISHIMOTO, TADAMITSU, KIKUTANI, HITOSHI
Format:	Patent
Sprache:	dan
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	An object of the present application is to provide new anti-Fc epsilon R-antibodies which enable B cells to be identified at a specific differentiation stage as well enabling the different degrees of atopy and Fc epsilon -receptor expression to be defined as a result by the showing that Fc epsilon R is a B cell specific phenotype marker, the expression of which is strictly correlated with the differentiation stage of B cells, especially with the isotype switching in B cells. Therefore, Fc epsilon R positive B cells can be recognized by detection with the new antibodies of the expressed Fc epsilon R, e.g. the expressed Fc epsilon R in supernatant or biological fluid having a molecular weight of about 25 Kd, and the use thereof in an ELISA. An further object are hybrid cell lines producing these antibodies.