NYE TRIPEL-HELISK POLYPEPTIDER UDEN BINDINGSAFFINITET FOR FC-DOMÆNET AF IMMUNOGLOBULIN OG ANVENDELSER DERAF

NYE TRIPEL-HELISK POLYPEPTIDER UDEN BINDINGSAFFINITET FOR FC-DOMÆNET AF IMMUNOGLOBULIN OG ANVENDELSER DERAF

The present invention relates to the field of protein engineering and purification and relates in particular to novel polypeptides having a triple-helical structure and lacking binding affinity for the Fc domain of immunoglobulin. The invention further relates to uses of the novel non-Fc binding pol...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ZWARG, Madlen, FIEDLER, Erik, HAUPTS, Ulrich
Format: Patent
Sprache:dan
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:The present invention relates to the field of protein engineering and purification and relates in particular to novel polypeptides having a triple-helical structure and lacking binding affinity for the Fc domain of immunoglobulin. The invention further relates to uses of the novel non-Fc binding polypeptides in technical applications such as affinity chromatography, as well as in therapy and diagnostics. In addition, the present invention relates to a method of reducing the binding affinity of a polypeptide having a triple-helical structure for the Fc domain of immunoglobulin.