OPTIMERET VÆRT/VEKTOR-SYSTEM TIL FREMSTILLING AF BESKYTTENDE MONO- OG MULTIVALENTE SUBUNIT-VACCINER BASERET PÅ GÆREN KLUYVEROMYCES LACTIS

OPTIMERET VÆRT/VEKTOR-SYSTEM TIL FREMSTILLING AF BESKYTTENDE MONO- OG MULTIVALENTE SUBUNIT-VACCINER BASERET PÅ GÆREN KLUYVEROMYCES LACTIS

Described herein are recombinant Kluyveromyces lactis (K. lactis) yeasts which are capable of the highly efficient expression of one or more foreign proteins and are suitable for use as a vaccine for generating a protective immune response against pathogens. The invention provides in particular K. l...

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Bibliographische Detailangaben
Hauptverfasser: HÜHRLIMANN, Hans Caspar, GEBAUER, Mandy, BEHRENS, Martina, BEHRENS, Sven-Erik, BREUNIG, Karin
Format: Patent
Sprache:dan
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:Described herein are recombinant Kluyveromyces lactis (K. lactis) yeasts which are capable of the highly efficient expression of one or more foreign proteins and are suitable for use as a vaccine for generating a protective immune response against pathogens. The invention provides in particular K. lactis strains for the targeted cloning of foreign antigen-coding nucleic acids into the yeast genome of the K. lactis strain, which is characterized in that the K. lactis strain has integrated expression cassettes for foreign antigens as an alternative or in addition to the KILAC4 locus on the KIURA3-20 locus (KLLA0E22771g) and/or on the KIMET5-1 locus (KLLA0B03938g). The invention further relates to integrative expression vectors and to methods for producing the K. lactis strains of the invention as well as to the use thereof as vaccines.