IKKE-KOVALENT SAMLET BIOMATRIXLAG

The present invention provides a biomatrix layer comprising, consisting essentially of or consisting of a sulfated oligosaccharide at a concentration in the range of 0.1 µM to 250 µM and a peptide-polyethylene glycol-conjugate according to formula (I): PEG-R1-(BX)n(I) wher...

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Bibliographische Detailangaben
Hauptverfasser:	ZHANG, Yixin, WIEDUWILD, Robert, WETZEL, Richard, HUSMAN, Dejan, THOMAS, Alvin
Format:	Patent
Sprache:	dan
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides a biomatrix layer comprising, consisting essentially of or consisting of a sulfated oligosaccharide at a concentration in the range of 0.1 µM to 250 µM and a peptide-polyethylene glycol-conjugate according to formula (I): PEG-R1-(BX)n(I) wherein B is lysine or arginine, X is selected from alanine, glycine, serine, threonine, tyrosine, glutamic acid or aspartic acid and n is an integer selected from 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 and 20; R 1 may be absent or is a peptide comprising 5 to 30 amino acids; PEG is comprised at a concentration in the range of 0.1 µM to 250 µM ; R1, if present, is comprised at a concentration in the range of 0.1 µM to 1000 µM; (BX)n is comprised at a concentration in the range of 0.25 µM to 250 µM. The invention further relates to processes for assembling the biomatrix layer. The biomatrix layer can be used in various biomedical applications, such as neuroprostheses, biosensors, nerve grafts, cell culture and encapsulation of cells and microorganisms as well as for drug delivery.