PIPERIDINYL- OG PIPERAZINYLSUBSTITUEREDE HETEROAROMATISKE CARBOXAMIDER SOM MODULATORER AF GPR6

PIPERIDINYL- OG PIPERAZINYLSUBSTITUEREDE HETEROAROMATISKE CARBOXAMIDER SOM MODULATORER AF GPR6

Disclosed are compounds of Formula 1 and pharmaceutically acceptable salts thereof, wherein L, R4, R5, R8, R10, R11, X1, X2, X3, X9, X12, and Z are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions...

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Bibliographische Detailangaben
Hauptverfasser: MURPHY, Sean, GREEN, Jason, KUEHLER, Jon, JONES, Benjamin, MONENSCHEIN, Holger, HOPKINS, Maria, KIRYANOV, Andre A, NIXEY, Thomas, SUN, Huikai
Format: Patent
Sprache:dan
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Disclosed are compounds of Formula 1 and pharmaceutically acceptable salts thereof, wherein L, R4, R5, R8, R10, R11, X1, X2, X3, X9, X12, and Z are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating diseases, disorders, and conditions associated with GPR6.