FORBINDELSER, FREMGANGSMÅDE TIL OPNÅELSE AF FORBINDELSERNE, FARMACEUTISK SAMMENSÆTNING, ANVENDELSE AF FORBINDELSERNE OG FREMGANGSMÅDE TIL BEHANDLING AF PSYKIATRISKE LIDELSER OG/ELLER SØVNFORSTYRRELSER

The present invention relates to novel and inventive pharmacologically active benzimidazole derivative compounds, which surprisingly have high affinity for melatonin MT1 and MT2 receptors and low affinity for CYP450 complex enzymes, specially CYP1A2. The present invention also relates to novel and i...

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Hauptverfasser:	FELYPE ZANETI DE AZEVEDO, Hatylas, WATANABE DA COSTA, Renata, MANNOCHIO DE SOUZA RUSSO, Elisa, MASCARELLO, Alessandra, RUCH WERNECK GUIMARÃES, Cristiano, FREIRE TORRES RUSSO, Valter
Format:	Patent
Sprache:	dan
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to novel and inventive pharmacologically active benzimidazole derivative compounds, which surprisingly have high affinity for melatonin MT1 and MT2 receptors and low affinity for CYP450 complex enzymes, specially CYP1A2. The present invention also relates to novel and inventive routes of synthesis of these compounds, pharmaceutical compositions comprising the compounds and the use of these compounds in the treatment of individuals affected by psychiatric disorders and/or sleep disorders related to these receptors (specially depression, anxiety, circadian cycle disorders), in addition to process for producing the composition.