DK341774

Preparation of novel 2-carbalkoxyamino-5(6)-benzimidazole phenyl ethers of the formula I in which R1 denotes alkyl having 1 to 4 carbon atoms, phenyl or p-nitrophenyl; R2 and R3, in each case independently of one another, denote hydrogen, hydroxyl, alkoxy having 1 to 4 carbon atoms, halogen, trifluo...

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Hauptverfasser: LOEWE H, DYWEL D, KIRSCH R, URBANIETZ J
Format: Patent
Sprache:eng
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Zusammenfassung:Preparation of novel 2-carbalkoxyamino-5(6)-benzimidazole phenyl ethers of the formula I in which R1 denotes alkyl having 1 to 4 carbon atoms, phenyl or p-nitrophenyl; R2 and R3, in each case independently of one another, denote hydrogen, hydroxyl, alkoxy having 1 to 4 carbon atoms, halogen, trifluoromethyl, alkyl having 1 to 4 carbon atoms or carbalkoxy having 1 to 4 carbon atoms in the alkoxy radical; R4 denotes hydrogen or chlorine; and X denotes oxygen or sulphur. The compounds of the formula I are useful chemotherapeutics and are suitable for the control of parasitic disorders in humans and animals. They are particularly active against a large number of helminths, their activity being particularly pronounced against gastrointestinal strongylidae. The compounds of the formula I are prepared by reacting appropriately substituted 2-aminobenzimidazoles with carbonic acid esters.