KNOGLETILFØRSELSKONJUGATER OG FREMGANGSMÅDE TIL ANVENDELSE HERAF TIL MÅLRETNING AF PROTEINER MOD KNOGLE

The invention relates to a pharmaceutical composition comprising a bone delivery conjugate having the structure Z-sALP-Y-Dn-X, wherein X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino...

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Bibliographische Detailangaben
Hauptverfasser: CRINE, Philippe, BOILEAU, Guy, LEMIRE, Isabelle, Loisel, Thomas P
Format: Patent
Sprache:dan
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Beschreibung
Zusammenfassung:The invention relates to a pharmaceutical composition comprising a bone delivery conjugate having the structure Z-sALP-Y-Dn-X, wherein X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; Dn is a poly aspartate, wherein n=10 to 16; and sALP is a soluble alkaline phosphatase and uses thereof.