EGF(A)-ANALOGER MED FEDTSYRESUBSTITUENTER

EGF(A)-ANALOGER MED FEDTSYRESUBSTITUENTER

The invention relates to compounds derived from the EGF(A) domain of LDL-R, in particular compounds comprising a peptide analogue of the wild-type EGF(A) (LDL-R(293-332)) sequence and at least one substituent comprising at least one fatty acid group. The invention also relates to a pharmaceutical co...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: RASMUSSEN, Salka Elbøl, CHEN, Jianhe, LAU, Jesper F, WIECZOREK, Birgit, LINDEROTH, Lars, GARIBAY, Patrick William, THØGERSEN, Henning, KODRA, János Tibor
Format: Patent
Sprache:dan
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The invention relates to compounds derived from the EGF(A) domain of LDL-R, in particular compounds comprising a peptide analogue of the wild-type EGF(A) (LDL-R(293-332)) sequence and at least one substituent comprising at least one fatty acid group. The invention also relates to a pharmaceutical composition thereof and use a medicament. The novel EGF(A) compounds of the invention are useful as treatment e.g. in the field of cholesterol lowering, dyslipidaemia and cardiovascular disease.