5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDIN-2,4-DION-DERIVATIVER DER ANVENDER ADAMTS INHIBITORER TIL BEHANDLING AF OSTEOARTHRITIS

The present invention discloses compounds according to formula I:Wherein R1, R2, R3a, R3b, and Cy are as defined herein.The present invention relates to compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same, and the compounds of formula I for use...

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Bibliographische Detailangaben
Hauptverfasser:	JARY, Helène, Marie, BREBION, Franck, Laurent, DE CEUNINCK, Frédéric, André, ALVEY, Luke, Jonathan, VARIN, Marie, Laurence, Claire, AMANTINI, David, GOSMINI, Romain, Luc, Marie, DEPREZ, Pierre, Marc, Marie, Joseph, PEIXOTO, Christophe, POP-BOTEZ, Iuliana, Ecaterina
Format:	Patent
Sprache:	dan
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention discloses compounds according to formula I:Wherein R1, R2, R3a, R3b, and Cy are as defined herein.The present invention relates to compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same, and the compounds of formula I for use in methods of treatment and for use in methods of prophylaxis and/or treatment of inflammatory conditions, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis.