GAMMADELTA-T-CELLEEKSPANSIONSPROCEDURE

GAMMADELTA-T-CELLEEKSPANSIONSPROCEDURE

A method for expanding a population of γδ T-cells is provided in which isolated activated Peripheral Blood Mononuclear Cells (PBMCs) are cultured in a medium comprising transforming growth factor beta (TGF-β) under conditions in which the production of effector yδ T-cells having therapeutic activity...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MAHER, John, BEATSON, Richard Esmond, PARENTE PEREIRA PURI, Ana Catarina
Format: Patent
Sprache:dan
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:A method for expanding a population of γδ T-cells is provided in which isolated activated Peripheral Blood Mononuclear Cells (PBMCs) are cultured in a medium comprising transforming growth factor beta (TGF-β) under conditions in which the production of effector yδ T-cells having therapeutic activity against malignant disease is favored. The use of TGF-β in the production of effector cells in particular vγ9vδ2 T-cells is also described and claimed.