6,7-DIHYDROPYRAZOLO[1,5-A]PYRAZIN-4(5H)-ONFORBINDELSER OG DERES ANVENDELSE SOM NEGATIVE ALLOSTERISKE MODULATORER AF MGLU2-RECEPTORER

6,7-DIHYDROPYRAZOLO[1,5-A]PYRAZIN-4(5H)-ONFORBINDELSER OG DERES ANVENDELSE SOM NEGATIVE ALLOSTERISKE MODULATORER AF MGLU2-RECEPTORER

The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives as negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 2 ("mGluR2"). The invention is also directed to pharmaceutical compositions comprising such compounds, to p...

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Bibliographische Detailangaben
Hauptverfasser: TRABANCO-SUÁREZ, Andrés, Avelino, VAN GOOL, Michiel, Luc, Maria, ALONSO-DE DIEGO, Sergio-Alvar, DELGADO-GONZÁLEZ, Óscar, ANDRÉS-GIL, José, Ignacio
Format: Patent
Sprache:dan
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives as negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 2 ("mGluR2"). The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention or treatment of disorders in which the mGluR2 subtype of metabotropic receptors is involved.