KRYSTALLINSKE FORMER AF 2-(TERT-BUTYLAMINO)-4-((1R, 3R, 4R)-3-HYDROXY-4-METHYLCYCLOHEXYLAMINO)-PYRIMIDIN-5-CARBOXAMID

The invention provides a method of preparing compound of formula (iv),by contacting the compound of formula (iii) with R1NH2 in the presence of a base or a Lewis acid, in a solvent as defined herewith. The invention further provides a compound of formula (iii),and tautomers thereof, wherein R2 is su...

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Hauptverfasser: BOERSEN, Nathan Andrew, BEAUCHAMPS, Marie Georges, NAGY, Mark A, YONG, Kelvin Hin-yeong, KOTHARE, Mohit Atul, MUSLEHIDDINOGLU, Jale, Man, Hon-wah, HUANG, Lianfeng, ZOU, Daozhong, LI, Ying, FERRETTI, Antonio Christian, XU, Jean, Hilgraf, Robert, ZOU, Nanfei
Format: Patent
Sprache:dan
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Zusammenfassung:The invention provides a method of preparing compound of formula (iv),by contacting the compound of formula (iii) with R1NH2 in the presence of a base or a Lewis acid, in a solvent as defined herewith. The invention further provides a compound of formula (iii),and tautomers thereof, wherein R2 is substituted or unsubstituted C1-8 alkyl, or substituted saturated cycloalkyl as defined herein.