Anti-komplementfaktor C1Q antistoffer og anvendelser deraf

The present invention relates to an isolated anti-Clq antibody comprising a light chain comprising a light chain variable domain and a heavy chain comprising a heavy chain variable domain, wherein: (i) the light chain variable domain comprises the HVR-L1 comprising the amino acid sequence of SEQ ID...

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Bibliographische Detailangaben
Hauptverfasser:	ROSENTHAL, Arnon, LEVITEN, Michael
Format:	Patent
Sprache:	dan
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to an isolated anti-Clq antibody comprising a light chain comprising a light chain variable domain and a heavy chain comprising a heavy chain variable domain, wherein: (i) the light chain variable domain comprises the HVR-L1 comprising the amino acid sequence of SEQ ID NO:5, HVR-L2 comprising the amino acid sequence of SEQ ID NO:6, and HVR-L3 comprising the amino acid sequence of SEQ ID NO:7; and (ii) the heavy chain variable domain comprises the HVR-H1 comprising the amino acid sequence of SEQ ID NO:9, HVR-H2 comprising the amino acid sequence of SEQ ID NO:10, and HVR-H3 comprising the amino acid sequence of SEQ ID NO:11; and wherein the antibody has a dissociation constant (KD) for human Clq of less than 1nM.