ENZYMATIC ENCODING METHODS FOR EFFICIENT SYNTHESIS OF LARGE LIBRARIES

Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reactio...

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Hauptverfasser:	PEDERSEN, Henrik, HOLTMANN, Anette, NØRREGAARD-MADSEN, Mads, DE LEON, Dean, Thisted, Thomas, Lundorf, Mikkel Dybro, Husemoen, Gitte Nystrup, Andersen, Anne Lee, KALDOR, Ditte Kievsmose, Godskesen, Michael Anders, Dolberg, Johannes, Kronberg, Tine Titilola Akinleminu, PETERSEN, Lene, Jensen, Kim Birkebæk, GOLDBECH, Anne, JAKOBSEN, Søren Nyboe, Olsen, Eva Kampmann, Sørensen, Anders Malling, Sams, Christian Klarner, Hansen, Anders Holm, GOLIAEV, Alex Haahr, Glad, Sanne Schrøder, Neve, Søren, FRESKGÅRD, Per-Ola, Franch, Thomas, Felding, Jakob, Sløk, Frank Abildgaard
Format:	Patent
Sprache:	dan
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMBINATORIAL CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).