PYRAZOLOOE3,4-GAAQUINOLIN-, PYRIDOOE2,3-GAA-QUINAZOLIN-, THIAZOLOOE4,5-GAAQUINOLIN-, OXAZOLOOE4,5-GAAQUINOLIN- OG PYRROLOOE3,4-GAAQUINOLIN-DERIVATER SAMT FREMGANGSMAADE TIL FREMSTILLING HERAF

PYRAZOLOOE3,4-GAAQUINOLIN-, PYRIDOOE2,3-GAA-QUINAZOLIN-, THIAZOLOOE4,5-GAAQUINOLIN-, OXAZOLOOE4,5-GAAQUINOLIN- OG PYRROLOOE3,4-GAAQUINOLIN-DERIVATER SAMT FREMGANGSMAADE TIL FREMSTILLING HERAF

7- or 8-Substituted, partially hydrogenated pyrazolo[3,4-g]quinoline, thiazolo[4,5-g]quinoline, oxazolo[4,5-g]quinoline, and pyrrolo[3,4-g]quinoline derivatives, and 8- or 9-substituted, partially hydrogenated pyrido[2,3-g]quinazoline derivatives of formula: wherein: represents or are D-2 dopamine a...

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Bibliographische Detailangaben
Hauptverfasser: SCHAUS, JOHN MEHNERT, HUSER, DIANE LYNN
Format: Patent
Sprache:dan
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:7- or 8-Substituted, partially hydrogenated pyrazolo[3,4-g]quinoline, thiazolo[4,5-g]quinoline, oxazolo[4,5-g]quinoline, and pyrrolo[3,4-g]quinoline derivatives, and 8- or 9-substituted, partially hydrogenated pyrido[2,3-g]quinazoline derivatives of formula: wherein: represents or are D-2 dopamine agonists. 6-Oxo-1-substituted-octahydroquinolines and 6-oxo-1-substituted-decahydroquinolines which are additionally substituted in the 3- or 4-position are intermediates useful in preparation of the dopamine agonists. Acetals of 4,6-dioxo-1-substituted-decahydroquinoline 3-carboxylic acid esters enable synthesis of the foregoing compounds.