KOMBINATION AF ET ANTICANCERMIDDEL SÅSOM EN TYROSINKINASEHÆMMER OG EN STAT5-ANTAGONIST, FORTRINSVIS ET THIAZOLIDINDION TIL ELIMINERING AF HÆMATOLOGISKE CANCERSTAMCELLER IN VIVO OG TIL FOREBYGGELSE AF RECIDIV AF HÆMATOLOGISK CANCER

KOMBINATION AF ET ANTICANCERMIDDEL SÅSOM EN TYROSINKINASEHÆMMER OG EN STAT5-ANTAGONIST, FORTRINSVIS ET THIAZOLIDINDION TIL ELIMINERING AF HÆMATOLOGISKE CANCERSTAMCELLER IN VIVO OG TIL FOREBYGGELSE AF RECIDIV AF HÆMATOLOGISK CANCER

Provided are methods for eliminating hematologic cancer stem cells in vivo, and thus preventing cancer relapse. The methods comprise a Signal Transducer and Activator of Transcription 5 (STAT5) antagonist (e.g., a PPARγ agonist) after the patient has had ana initial course of treatment with an anti-...

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Hauptverfasser: LEBOULCH, Philipe, ROUSSELOT, Philippe, PROST, Stephane, LE DANTEC, Mikael, KIRSZENBAUM, Marek
Format: Patent
Sprache:dan
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Provided are methods for eliminating hematologic cancer stem cells in vivo, and thus preventing cancer relapse. The methods comprise a Signal Transducer and Activator of Transcription 5 (STAT5) antagonist (e.g., a PPARγ agonist) after the patient has had ana initial course of treatment with an anti-cancer agent (e.g., a TKI), to eliminate residual cancer stem cells which cause relapse.