FREMGANGSMÅDE TIL FREMSTILLING AF 3,5-DISUBSTITUERET 1,2,4-OXADIAZOLER

FREMGANGSMÅDE TIL FREMSTILLING AF 3,5-DISUBSTITUERET 1,2,4-OXADIAZOLER

Provided herein are processes for the preparation of 3,5-disubstituted-1,2,4-oxadiazoles and salts thereof comprising reacting a N-hydroxyamidine with an acyl chloride in a reaction mixture comprising a water-immiscible organic solvent and an aqueous base at relatively low reaction temperatures.

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Bibliographische Detailangaben
Hauptverfasser: GRAHAM, Charles Richard, BROWN, David Louis, MILLER, William Harold
Format: Patent
Sprache:dan
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Provided herein are processes for the preparation of 3,5-disubstituted-1,2,4-oxadiazoles and salts thereof comprising reacting a N-hydroxyamidine with an acyl chloride in a reaction mixture comprising a water-immiscible organic solvent and an aqueous base at relatively low reaction temperatures.