Makrocykliske derivater til behandling af proliferative sygdomme

The invention relates to compounds of formula (Φ) as further defined herein and to the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to the uses thereof. The compounds and salts of the present invention inhibit anaplastic lymphoma...

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Bibliographische Detailangaben
Hauptverfasser:	SACH, Neal, William, KATH, John, Charles, BAILEY, Simon, JOHNSON, Ted, William, HOFFMAN, Robert, Louis, DEAL, Judith, Gail, MCTIGUE, Michele, Ann, KANIA, Robert, Steven, BURKE, Benjamin, Joseph, CUI, Jingrong, Jean, HUANG, Qinhua, LE, Phuong, Thi, Quy, RICHARDSON, Paul, Francis, PALMER, Cynthia, Louise, COLLINS, Michael, Raymond
Format:	Patent
Sprache:	dan
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to compounds of formula (Φ) as further defined herein and to the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to the uses thereof. The compounds and salts of the present invention inhibit anaplastic lymphoma kinase (ALK) and/or EML4-ALK and are useful for treating or ameliorating abnormal cell proliferative disorders, such as cancer.