Antigen-bindende molekyle til at fremme forsvinden af antigen ved hjælp af Fc RIIB

Antigen-bindende molekyle til at fremme forsvinden af antigen ved hjælp af Fc RIIB

The present invention provides antigen-binding molecules containing (i) an antigen-binding domain whose antigen-binding activity varies depending on ion concentration conditions, (ii) an Fcγ-binding domain having Fcy RIIb-selective binding activity, and (iii) an FcRn-binding domain having FcRn-bindi...

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Bibliographische Detailangaben
Hauptverfasser: HARAYA, Kenta, IWAYANAGI, Yuki, KADONO, Shojiro, MIMOTO, Futa, KATADA, Hitoshi, MAEDA, Atsuhiko, IGAWA, Tomoyuki
Format: Patent
Sprache:dan
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:The present invention provides antigen-binding molecules containing (i) an antigen-binding domain whose antigen-binding activity varies depending on ion concentration conditions, (ii) an Fcγ-binding domain having Fcy RIIb-selective binding activity, and (iii) an FcRn-binding domain having FcRn-binding activity under an acidic pH range condition, and methods of decreasing plasma antigen concentration as compared to before administering the molecule, which include the step of administering the molecule.