Hurtigt dissocierende dopamin-2-receptor-antagonister

The present invention relates to 4-aryl-6-piperazin-1-yl-3-substituted-pyridazines that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medici...

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Bibliographische Detailangaben
Hauptverfasser: LANGLOIS, XAVIER, JEAN, MICHEL, BARTOLOME-NEBREDA, JOSE, MANUEL, VAN GOOL, MICHIEL, LUC, MARIA, MACDONALD, GREGOR, JAMES
Format: Patent
Sprache:dan
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Zusammenfassung:The present invention relates to 4-aryl-6-piperazin-1-yl-3-substituted-pyridazines that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects.