Crystalline forms of (R)-4-[4-(dimethylamino)-1-(4'-fluorophenyl)-hydroxybutyl]-3-(hydroxymethyl)-benzonitrile free base and (S)-4-[4-(dimethylamino)-1-(4'-fluoro-phenyl)-hydroxybutyl]-3-(hydroxymethyl)-benzonitrile free base and of racemic 4-[4-(dimethylamino)-1-(4'-fluorophenyl)-hydroxybutyl]-3-(hydroxyl-methyl)-benzonitrile toluene hemisolvate

Crystalline forms of (R)-4-[4-(dimethylamino)-1-(4'-fluorophenyl)-hydroxybutyl]-3-(hydroxymethyl)-benzonitrile free base and (S)-4-[4-(dimethylamino)-1-(4'-fluoro-phenyl)-hydroxybutyl]-3-(hydroxymethyl)-benzonitrile free base and of racemic 4-[4-(dimethylamino)-1-(4'-fluorophenyl)-hydroxybutyl]-3-(hydroxyl-methyl)-benzonitrile toluene hemisolvate

The present invention relates to processes for manufacture of escitalopram comprising crystallization of the free base forms of the intermediates of (R)-4-[4-(dimethylamino)-1-(4'-fluorophenyl)-hydroxybutyl]-3-(hydroxymethyl)-benzonitrile, (S)-4-[4-(dimethylamino)-1-(4'-fluorophenyl)- hydr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Christensen, Troels V, Faveri, Carla De, Diego, Heidi Lopez de, Dancer, Robert James, Huber, Florian Anton Martin, Nielsen, Martin Anker
Format: Patent
Sprache:dan ; eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention relates to processes for manufacture of escitalopram comprising crystallization of the free base forms of the intermediates of (R)-4-[4-(dimethylamino)-1-(4'-fluorophenyl)-hydroxybutyl]-3-(hydroxymethyl)-benzonitrile, (S)-4-[4-(dimethylamino)-1-(4'-fluorophenyl)- hydroxy-butyl]-3-(hydroxymethyl)-benzonitrile and racemic 4-[4-(dimethylamino)-1-(4'-fluoro-phenyl)-hydroxybutyl]-3 (hydroxyl-methyl)-benzonitrile toluene hemisolvate. The present invention also relates to escitalopram and pharmaceutically acceptable salts thereof ob-tained from said processes.